N-Desmethyl Sildenafil

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

N-Desmethyl Sildenafil (Desmethylsildenafil) 是 Sildenafil 的主要代谢物。Sildenafil 是一种有效的 5 型磷酸二酯酶 (PDE5) 抑制剂。

N-Desmethyl Sildenafil (Desmethylsildenafil) is a major metabolite of Sildenafil. Sildenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor.

N-Desmethyl Sildenafil increases the amplitude of electroretinogram (ERG) recorded from the dark-adapted isolated rat retina, most probably through the enhancement of the photoreceptor cell response. The formation of N-Desmethyl Sildenafil is examined using CYP3A supersomes co-expressing human P450 oxidoreductase and cytochrome b5. N-Desmethyl Sildenafil is catalyzed by CYP3A4, CYP3A5, and to a lesser extent by CYP3A7.

——

——

Others

Other Targets

Drug Metabolite

——

——

139755-82-1

460.55

C21H28N6O4S

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 250 mg/mL (542.83 mM; 超声助溶 )

CCCc1nn(C)c2c1[nH]c(nc2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCNCC1

——

(-20℃)

With Ice Pack

≥ 2 years